Circulating microRNA plasma profile in MuSK+ myasthenia gravis
نویسندگان
چکیده
منابع مشابه
Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis
Myasthenia gravis (MG) patients with antibodies against the muscle specific tyrosine kinase (MuSK+) have predominantly involvement of cranio-bulbar muscles and do not display thymus pathology, as do acetylcholine receptor antibody seropositive (AChR+) MG patients. In search of novel biomarkers for MuSK+ MG, we evaluated circulating serum microRNAs. Four analyzed microRNAs were specifically elev...
متن کاملMyasthenia gravis patients with anti-MuSK antibodies.
In myasthenia gravis (MG) patients without detectable anti-acetylcholine receptor (anti-AChR) antibody, referred to as seronegative myasthenia gravis patients, there is a variable proportion of patients with antibodies against the muscle-specific kinase (MuSK). MuSK antibodies were found in 8 (29.6%) of our 27 patients with generalized MG without anti-AChR antibodies. All these patients were fe...
متن کاملIncreased complement consumption in MuSK-antibody-positive myasthenia gravis patients.
OBJECTIVE To investigate the activation of different complement pathways in myasthenia gravis (MG) subtypes. SUBJECTS AND METHODS Levels of complement breakdown products for different complement pathways were measured using ELISA in sera of acetylcholine receptor antibody (AChR-Ab)-positive (n = 21), muscle-specific receptor tyrosine kinase (MuSK)-Ab-positive (n = 23) and seronegative general...
متن کاملRepetitive Nerve Stimulation in MuSK-Antibody-Positive Myasthenia Gravis
BACKGROUND AND PURPOSE Responses to repetitive nerve stimulation (RNS) in patients with muscle-specific tyrosine kinase (MuSK) antibody (Ab)-positive myasthenia gravis (MG) vary depending on the muscles tested. We analyzed the RNS responses of limb and facial muscles in MuSK-Ab-positive and acetylcholine receptor (AChR)-Ab-negative MG (MuSK MG) and MuSK-Ab-negative and AChR-Ab-negative [double-...
متن کاملCirculating immune complexes in myasthenia gravis.
Circulating immune complexes were assayed employing the method recently described by Barnett and Chia in a group of patients with myasthenia gravis. The subjects were classified according to clinical severity and immune complexes were sought before and after thymectomy. The operated subjects were further divided into those with thymoma or thymic hyperplasia. Antigenantibody complexes were highe...
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ژورنال
عنوان ژورنال: Journal of Neuroimmunology
سال: 2018
ISSN: 0165-5728
DOI: 10.1016/j.jneuroim.2018.10.003